C3 Agentic AI platform provides a secure, scalable foundation across national healthcare programs
Redwood City, California — December 4, 2025 — C3 AI (NYSE: AI), an enterprise AI application software company, announced today that the U.S. Department of Health and Human Services (HHS) has selected C3 AI to build a secure, scalable data foundation integrated across the National Institutes of Health (NIH) and Centers for Medicare and Medicaid Services (CMS).
C3 AI integrates disease-specific NIH data enclaves with Medicare, Medicaid, insurance claims, and state registry datasets. HHS uses the C3 Agentic AI platform to improve data quality and governance, enabling new research, analysis, and applications while enforcing strict privacy and security requirements. Additionally, the Department will use C3 Agentic AI to automate complex and labor-intensive administrative workflows. This new data infrastructure is designed to support biomedical research, program integrity, and public health analysis.
said Stephen Ehikian, CEO of C3 AI. “HHS is taking a major step toward a modern, AI-enabled architecture for national health data.” “The C3 Agentic AI platform is built to integrate large and complex federal systems. It provides a secure, transparent, and interoperable foundation that enables HHS to accelerate biomedical discoveries, strengthen program integrity, and improve public health outcomes for millions of Americans.”
“At Fleet Health, we believe that data can save lives. Our collaboration with C3 AI brings together advanced AI capabilities and high-fidelity, real-world data in a partnership built on a zero trust framework,” said Nabeel Qureshi, CEO of Fleet Health. “This initiative aims to provide researchable health data that supports important national programs and population health initiatives. Together, we can unlock the full potential of health data and improve outcomes for millions of people across the country.”
