In the run-up to the Fourth of July long weekend, President Donald Trump, in a late-night social media post, accused his biggest critics of suffering from a hypothetical “Trump Derangement Syndrome.”
In an AI video posted to President Trump’s Truth social account just before midnight Wednesday, the president appears as “Dr. Trump” and claims, in the calm tone of a pharmaceutical company ad, that “there is a treatment plan” for people suffering from “Trump Derangement Syndrome.” The clip then features fake testimonials from Rosie O’Donnell, “The View” co-host Whoopi Goldberg, and Robert De Niro, who describe their own “TDS” symptoms. AI-generated versions of Julia Roberts, John Leguizamo, and Edward Norton also appear as alleged victims of TDS.
President Trump appears to believe that “TDS” is a real medical condition, saying at a White House event in May, “I hear it’s actually a disease” (via Mediaite).
After Rob Reiner and his wife, Michelle, were murdered in December, President Trump wrote in a post on Truth Social that the director and actor “reportedly died from the anger he provoked in others due to the severe, humiliating and incurable suffering of a debilitating illness known as Trump Derangement Syndrome (also known as TDS).”
In the fake “Dr. Trump” video, an AI-generated O’Donnell says, “I’ve been suffering for over 10 years, but after listening to Dr. Trump, I’m starting to see some results.” Fake De Niro says, “I had no idea how much this was affecting my life. My career stagnated. I was hardly recognized anymore. I just needed help. I couldn’t eat, I couldn’t sleep, I was always angry. I made everyone around me unhappy.”
“I feel like I’ve aged 20 years in the last two years,” Roberts’ AI avatar said in the video, adding that she was starting to “worry about my future.”
What is the cure for TDS? Here’s what Dr. Trump said in the kicker of the video: “Stop the fake news. Say your prayers, and if you feel anxious, drink a Diet Coke like I do, and you’ll see a noticeable change in your life.”
Trump regularly posts images and videos generated by AI. That included a post this spring depicting Trump as a Christ-like figure healing the sick, which has since been deleted, but Trump told reporters he thought he was portraying himself as a doctor.
Trump’s social accounts also share AI images of himself dressed as the Pope, as well as images of himself as Superman and other DC superheroes. In October 2025, the president shared a video showing Trump riding in a fighter jet and acting as king dropping tons of feces on No Kings protesters in New York City.
And in February, President Trump posted an AI video taken from a Lion King-themed meme that depicted President Barack Obama and Michelle Obama as monkeys. The White House initially defended the post as satire, but the video was removed after backlash from some Republicans. President Trump did not apologize for posting the racist video, telling reporters, “I liked the first part. I just saw it and told it. I don’t think anyone reviewed it all the way through.”
Watch the fake “Dr. Trump” video.
