Machine learning-based prediction of the outcomes of G-CSF-induced hematopoietic stem cell recruitment in healthy volunteers

Machine Learning


  • Saad A, De Lima M, Anand S, Bhatt VR, Bookout R, Chen G, et al. Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Cancer Netw. 2020; 18:599–634. https://doi.org/10.6004/jncn.2020.0021.

    Article CAS Google Scholar

  • Vo LT, Daley GQ. de novo generation of HSCs from somatic and pluripotent stem cell sources. blood. 2015; 125:2641–2648. https://doi.org/10.1182/blood-2014-10-570234.

    ArticleCAS PubMed Central Google Scholar

  • Lite de, Gats and AJ, Gulati AP, Johnson FL, Weissman IL. Physiological migration of hematopoietic stems and progenitor cells. Science. 2001; 294:1933–1936. https://doi.org/10.1126/science.1064081.

    Article CAS Google Scholar

  • Richman CM, Weiner RS, Yankee RA. Increase in circulating stem cells after human chemotherapy. blood. 1976; 47:1031–1039.

    Article CAS Google Scholar

  • Henig I, Zuckerman T. Hematopoietic Stem Cell Transplantation – Evolution and Future Perspectives in 50 Years. Rambam Maimonides Med J. 2014; 5(4): E0028 https://doi.org/10.5041/rmmj.10162.

    ArticlePubMed Central Google Scholar

  • Adra N, Abonour R, Althouse SK, Albany C, Hanna NH, Einhorn LH. High-dose chemotherapy and autologous peripheral blood stem cell transplantation for recurrent metastatic germ cell tumors: an Indiana University experience. J Clin Oncol J Am Soc Clin Oncol. 2017; 35:1096–1102. https://doi.org/10.1200/jco.2016.69.5395.

    ArticleGoogle Scholar

  • Schmitz N, Linch DC, Dreger P, Goldstone AH, Boogaerts MA, Ferrant A, et al. Randomized trials of Philgrastim motorized peripheral blood progenitor cell transplants compared to autologous bone marrow transplants in patients with lymphoma. Lancet. 1996; 347:353–357. https://doi.org/10.1016/S0140-6736(96)90536-X.

    Article CAS Google Scholar

  • Hematopoietic rescue after high-dose chemotherapy using autologous peripheral blood progenitor cells or bone marrow, including Beyer J, Schwella N, Zingsem J, Strohscheer I, Schwaner I, and Oettle H: a randomized comparison. J Clin Oncol J Am Soc Clin Oncol. 1995; 13:1328–1335. https://doi.org/10.1200/jco.1995.13.6.1328.

    Article CAS Google Scholar

  • LB, Haylock DN, Kimber RJ, Juttner CA. High levels of circulating hematopoietic stem cells in very early remission from acute non-lymphoblastic leukemia and in very early remission in collection and cryopreservation. Br J Haematol. 1984; 58:399–410. https://doi.org/10.1111/j.1365-2141.1984.tb03987.x.

    Article CAS Google Scholar

  • Briddell RA, Hartley CA, Smith KA, McNiece IK. Recombinant rat stem cell factor is synergistic with mouse in vivo recombinant human granulocyte colony stimulating factor to recruit peripheral blood progenitors that increase repermeability. blood. 1993; 82:1720–1723.

    Article CAS Google Scholar

  • Mayer P, Lam C, Obenaus H, Liehl E, Besemer J. Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polynuclear neutrophils in non-human primates. blood. 1987; 70:206–213.

    Article CAS Google Scholar

  • Bio5192, a small molecule inhibitor of VLA-4, including Ramirez P, Rettig MP, Uy GL, Deych E, Holt MS, and Ritchey JK, recruits hematopoietic stems and progenitor cells. blood. 2009; 114:1340–1343. https://doi.org/10.1182/blood-2008-10-184721.

    ArticleCAS PubMed Central Google Scholar

  • Zaldivar F, Eliakim A, Radom-Aizik S, Leu SY, Cooper DM. Effects of short exercise on CD34+ stem cell circulation in early and late adolescent boys. Pediatr res. 2007; 61:491–495. https://doi.org/10.1203/pdr.0b013e3180332d36.

    ArticleGoogle Scholar

  • Juarez JG, Harun N, Thien M, Welschinger R, Baraz R, Pena AD, et al. sphingosine-1-phosphate promotes human trafficking and mobilization of hematopoietic stem cells by CXCR4 antagonists in mice. blood. 2012; 119:707–716. https://doi.org/10.1182/blood-2011-04-348904.

    Article CAS Google Scholar

  • Cline MJ, Golde DW. Mobilization of hematopoietic stem cells (CFU-C) into human peripheral blood by endotoxin. Exp Hematol. 1977; 5:186–190.

    CAS Google Scholar

  • Karpova D, Rettig MP, Dipersio JF. Mobilized Peripheral Blood: An updated perspective. F1000Research 2019;8, https://doi.org/10.12688/f1000research.21129.1

  • Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, et al. G-CSF strongly inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. blood. 2005; 106:3020–3027. https://doi.org/10.1182/blood-2004-01-0272.

    ArticleCAS PubMed Central Google Scholar

  • MicroRNA126, including Salvucci O, Jiang K, Gasperini P, Maric D, Zhu J, Sakakibara S, contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell recruitment by reducing the expression of vascular cell adhesion molecules. 2012; 97:818–826. https://doi.org/10.3324/haematol.2011.056945.

    ArticleCAS PubMed Central Google Scholar

  • Autotrans plants using peripheral blood stem cells recruited by cyclophosphamide to LB, Davy ML, Haylock DN, Dyson PG, Thorp D, and Juttner CA. Bone marrow transplant. 1989; 4:595–596.

    CAS Google Scholar

  • Pralixapho and G-CSF vs. Placebo and G-CSF for recruiting hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma, including Dipersio JF, Stadtmauer EA, Nademanee A, Microlef in, Stiff PJ, Kaufman JL. blood. 2009; 113:5720–5726. https://doi.org/10.1182/blood-2008-08-174946.

    Article CAS Google Scholar

  • Greenbaum AM, Link DC. Mechanisms of G-CSF-mediated hematopoietic stem and progenitor cell recruitment. leukemia. 2011; 25:211–217. https://doi.org/10.1038/LEU.2010.248.

    Article CAS Google Scholar

  • LB, Levesque JP, Herbert KE. There is insufficient treatment for patients who recruit hematopoietic stem cells. blood. 2011; 118:4530–4540. https://doi.org/10.1182/blood-2011-06-318220.

    Article CAS Google Scholar

  • Factors that influence the collection and engraftment of autologous peripheral blood stem cells, including Bensinger W, Appelbaum F, Rowley S, Storb R, Sanders J, and Lilleby K. J Clin Oncol J Am Soc Clin Oncol. 1995; 13:2547–2555. https://doi.org/10.1200/jco.1995.13.10.2547.

    Article CAS Google Scholar

  • The impact of various strategies of second-line stem cell harvesting on autograft outcomes in poor peripheral blood stem cell recruitment, including Goterris R, Hernández-Boluda JC, Teruel A, GómezC, Lis MJ, and Terol MJ. Bone marrow transplant. 2005; 36:847–853. https://doi.org/10.1038/sj.bmt.1705147.

    Article CAS Google Scholar

  • Fiala MA, Park S, Slade M, Dipersio JF, Stockerl-Goldstein KE. Reactivation of hematopoietic stem cells in healthy donors for allografting. transfusion. 2016; 56:2331–2335. https://doi.org/10.1111/trf.13688.

    ArticleCAS PubMed Central Google Scholar

  • Topol EJ. High-performance drugs: Convergence of human and artificial intelligence. Nut Med. 2019; 25:44–56. https://doi.org/10.1038/S41591-018-0300-7.

    Article CAS Google Scholar

  • Chen H, Liu J, Hua C, Feng J, Pang B, Cao D, and others Accurate classification of leukocytes by combining pre-trained renets and densennets with fraud mechanisms. BMC Bioinforma. 2022; 23:282 https://doi.org/10.1186/S12859-022-04824-6.

    ArticleGoogle Scholar

  • Arai Y, Kondo T, Fuse K, Shibasaki Y, Masuko M, Sugita J, and others machine learning algorithms are used to predict acute graft-versus-host disease after allografting. Blood Adv. 2019; 3:3626–3634. https://doi.org/10.1182/bloodadvances.2019000934.

    ArticlePubMed Central Google Scholar

  • A machine learning-based scoring model to predict hematopoietic stem cell recruitment in Xiang J, Shi M, Fiala MA, Gao F, Rettig MP, Uy GL, and other allogeneic donors. Blood Adv. 2022; 6:1991–2000. https://doi.org/10.1182/bloodadvances.2021005149.

    ArticleCAS PubMed Central Google Scholar

  • Heavy choices such as Farhadfar N, Hsu JW, Logan BR, Sees Ja, Chitphakdithai P, Sugrue MW: Choose the best G-CSF dosage for stem cell recruitment to optimize yield. Blood Adv. 2020; 4:706–716. https://doi.org/10.1182/bloodadvances.2019000923.

    ArticleCAS PubMed Central Google Scholar

  • Lengefeld J, Cheng CW, Maretich P, Blair M, Hagen H, McReynolds MR, and other cell sizes are determinants of stem cell potential during senescence. Sci Adv. 2021;7: EABK0271 https://doi.org/10.1126/sciadv.abk0271.

    ArticleCAS PubMed Central Google Scholar

  • Orkin SH, Zon Li. hematopoiesis: An evolving paradigm of stem cell biology. cell. 2008; 132:631–644. https://doi.org/10.1016/j.cell.2008.01.025.

    ArticleCAS PubMed Central Google Scholar

  • Current use of androgens in myelopathic disorders including Pagliuca S, Kulasekararaj AG, Eikema DJ, Piepenbroek B, Iftikhar R, Satti TM: Reports from the Severe Non-Tratable Anemia Party of the European Association for Blood and Bone Marrow Transplantation. Hematopoietics. 2024; 109:765–776. https://doi.org/10.3324/haematol.2023.282935.

    Article CAS Google Scholar

  • Bosi A, Barcellini W, Passamonti F, Fattizzo B. Use of androgens in myeloid disorders and myeloid neoplasms: a systematic review of mechanisms of action and clinical data. Blood Rev. 2023; 62:101132 https://doi.org/10.1016/j.blre.2023.101132.

    Article CAS Google Scholar

  • Cheang C, Law S, Ren J, Chan W, Wang C, Dong Z. Prevalence of hyperuricemia in the relationship between severe obesity and serum uric acid and severe obesity: a 10-year retrospective cross-sectional study in Chinese adults. Frontal public health. 2022;10:986954 https://doi.org/10.3389/fpubh.2022.986954.

    ArticlePubMed Central Google Scholar

  • Tan My, Mo Cy, Li F, Zhao Q. Association of serum uric acid and hypertriglyceridemia: Evidence front-end clinol from the National Health and Nutrition Survey (2007-2018). 2023;14:1215521 https://doi.org/10.3389/fendo.2023.1215521.

    ArticleGoogle Scholar

  • Yano T, Katayama Y, Sunami K, Deguchi S, Nawa Y, Hiramatsu Y, et al. Mobilization for allografting of G-CSF-induced peripheral blood stem cells: a comparative study of daily single and fractionated doses of G-CSF. Int J Hematol. 1997; 66:169–178. https://doi.org/10.1016/S0925-5710(97)00590-2.

    Article CAS Google Scholar

  • Randomized comparisons of recombinant human granulocyte colony stimulating factor (filgrastim) once and twice a day for stem cell recruitment in healthy donors for allografting, including KrögerN, Renges H, Krüger W, Gutensohn K, Löliger C, Carrero I. Br J Haematol. 2000; 111:761–765.

    Google Scholar



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