Bota Introduces SAION AI – Physics AI Platform for Biomanufacturing | For Enterprises

SAN FRANCISCO and HANGZHOU, China, March 10, 2026 /PRNewswire/ — New frontiers will emerge as AI reshapes the digital world through cognitive and generative capabilities. It’s physical AI — intelligent systems that perceive, reason, and act on the physical world.

Today, Bota announced SAION AI. The first physical AI platform for biomanufacturing.

SAION AI is not limited to this in silico design. Instead, it is a full-stack physics AI platform that integrates cognition, orchestration, and closed-loop execution through end-to-end experimentation to continuously optimize biological discovery and biomanufacturing.

SAION AI is built on a three-tier architecture: perception, orchestration, and execution..

Powered by large-scale language models, the platform integrates scientific reasoning and real-world experiment execution. This architecture enables seamless orchestration from biological system understanding to laboratory experiments, forming a self-optimizing closed loop for biomanufacturing.

Cognition: Multiscale biological understanding

The Cognition Layer is built on data from Bota’s Cell2Cloud Biofoundry, integrating tens of millions of experimental data points, millions of scientific publications and patents, and public biological databases. When combined with state-of-the-art AI4Science models, SAION AI advances multiscale understanding across the genetic, protein, cellular, and fermentation continuum, enabling systematic design and data-driven scientific decision-making.

Orchestration: Intelligent research coordination

The orchestration layer is centered around an agent harness orchestration engine that leverages LLM inference to orchestrate multi-agent collaboration, tool invocation, and end-to-end scientific workflows.

This layer decomposes complex objectives into structured tasks and integrates 316 specialized scientific tools to enable automated research workflows with dynamic routing and fault tolerance.

Execution: Autonomous experimental operation

Through Bota’s proprietary biological protocol language, SAION AI translates experimental designs into standardized instructions that directly drive laboratory hardware and feeds real-world data back to the cognitive layer, enabling continuous model improvement and accelerating research and development.

real world performance

SAION AI has proven sorter Validate its performance across multiple life science AI benchmarks and validate its capabilities as an AI Scientist system.

Main results

• Literature comprehension: 70.7% with LitQA+SuppQA — higher than major general-purpose models
• Sequence inference: 88.2% with SeqQA across DNA, RNA, and protein tasks.
• Genetic Engineering: 84.9% in Gene Editing and Cloning Benchmark.
• Scientific discovery: 89.6% on BAIS-SD benchmark.

Real-world validation confirmed that SAION AI can autonomously complete a complete study, from literature review to wet lab assembly, with over 90% accuracy.

Towards autonomous biomanufacturing

The launch of SAION AI moves biomanufacturing beyond traditional trial-and-error experimentation into an intelligent engineering field where AI and physical labs interact to accelerate discovery and industrial scale-up.

SAION AI Demo

Contact: bota.pr@bota.bio

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