World Health Organization. WHO Director-General’s Remarks at the Media Briefing on 2019-nCoV on 11 February 2020. https://www.who.int/director-general/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020Accessed 30 August 2025.
To KK, Sridhar S, Chiu KH, Hung DL, Li X, Hung IF, Tam AR, Chung TW, Chan JF, Zhang AJ, Cheng VC, Yuen KY. Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic. Emerg Microbes Infect. 2021;10(1):507–35. https://doi.org/10.1080/22221751.2021.1898291.
Lippi G, Sanchis-Gomar F, Henry BM. COVID-19 and its long-term sequelae: what do we know in 2023? Pol Arch Intern Med. 2023;133(4):16402. https://doi.org/10.20452/pamw.16402.
Castanares-Zapatero D, Chalon P, Kohn L, Dauvrin M, Detollenaere J, Maertens de Noordhout C, Primus-de Jong C, Cleemput I, Van den Heede K. Pathophysiology and mechanism of long covid: a comprehensive review. Ann Med. 2022;54(1):1473–87. https://doi.org/10.1080/07853890.2022.2076901.
Kharroubi S, Naja F, Diab-El-Harake M, Jomaa L. Food insecurity pre- and post the COVID-19 pandemic and economic crisis in Lebanon: prevalence and projections. Nutrients. 2021;13(9):2976. https://doi.org/10.3390/nu13092976.
Awijen H, Ben Zaied Y, Nguyen DK. Covid-19 vaccination, fear and anxiety: evidence from Google search trends. Soc Sci Med. 2022;297:114820. https://doi.org/10.1016/j.socscimed.2022.114820.
Millroth P, Frey R. Fear and anxiety in the face of COVID-19: negative dispositions towards risk and uncertainty as vulnerability factors. J Anxiety Disord. 2021;83:102454. https://doi.org/10.1016/j.janxdis.2021.102454.
Sher L. Psychiatric disorders and suicide in the COVID-19 era. QJM. 2020;113(8):527–28. https://doi.org/10.1093/qjmed/hcaa204.
Breslau J, Finucane ML, Locker AR, Baird MD, Roth EA, Collins RL. A longitudinal study of psychological distress in the United States before and during the COVID-19 pandemic. Prev Med. 2021;143:106362. https://doi.org/10.1016/j.ypmed.2020.106362.
Singh K, Kondal D, Mohan S, Jaganathan S, Deepa M, Venkateshmurthy NS, Jarhyan P, Anjana RM, Narayan KMV, Mohan V, Tandon N, Ali MK, Prabhakaran D, Eggleston K. Health, psychosocial, and economic impacts of the COVID-19 pandemic on people with chronic conditions in India: a mixed methods study. BMC Public Health. 2021;21(1):685. https://doi.org/10.1186/s12889-021-10708-w.
Munipalli B, Al-Soleiti M, Morris A, Rummans T. COVID-19: ramifications of the pandemic on mental health and substance abuse. Front Public Health. 2024;12:1401734. https://doi.org/10.3389/fpubh.2024.1401734.
Pettinicchio D, Maroto M, Chai L, Lukk M. Findings from an online survey on the mental health effects of COVID-19 on Canadians with disabilities and chronic health conditions. Disabil Health J. 2021;14(3):101085. https://doi.org/10.1016/j.dhjo.2021.101085.
The State Council Joint Prevention and Control Mechanism for COVID-19. Notice on further optimizing the implementation of COVID-19 prevention and control measures. 2021. https://www.gov.cn/xinwen/gwylflkjz217/index.htm. Accessed 30 August 2025.
Kim M, Yun B, Sim J, Cho A, Oh J, Kim J, Nambunmee K, Rozek LS, Yoon JH. Risk of psychological distress by decrease in economic activity, gender, and age due to COVID-19: a multinational study. Front Public Health. 2023;11:1056768. https://doi.org/10.3389/fpubh.2023.1056768.
Pförtner TK, Dohle S, Hower KI. Trends in educational disparities in preventive behaviours, risk perception, perceived effectiveness and trust in the first year of the COVID-19 pandemic in Germany. BMC Public Health. 2022;22(1):903. https://doi.org/10.1186/s12889-022-13341-3.
Blomqvist S, Högnäs RS, Virtanen M, Ad L, Magnusson Hanson LL. Job loss and job instability during the COVID-19 pandemic and the risk of depression and anxiety among Swedish employees. SSM Popul Health. 2023;22:101424. https://doi.org/10.1016/j.ssmph.2023.101424.
Klein DN, Kotov R, Bufferd SJ. Personality and depression: explanatory models and review of the evidence. Annu Rev Clin Psychol. 2011;7:269–95. https://doi.org/10.1146/annurev-clinpsy-032210-104540.
Buneviciene I, Bunevicius R, Bagdonas S, Bunevicius A. The impact of pre-existing conditions and perceived health status on mental health during the COVID-19 pandemic. J Public Health (oxf). 2022;44(1):e88–95. https://doi.org/10.1093/pubmed/fdab248.
Impara E, Bakolis I, Bécares L, Dasch H, Dregan A, Dyer J, Hotopf M, Stewart RJ, Stuart R, Ocloo J, Das-Munshi J. COVID-19 ethnic inequalities in mental health and multimorbidities: protocol for the COVEIMM study. Soc Psychiatry Psychiatr Epidemiol. 2022;57(12):2511–21. https://doi.org/10.1007/s00127-022-02305-y.
Kim SW, Park IH, Kim M, Park AL, Jhon M, Kim JW, Kang HJ, Ryu S, Lee JY, Kim JM. Risk and protective factors of depression in the general population during the COVID-19 epidemic in Korea. BMC Psychiatry. 2021;21(1):445. https://doi.org/10.1186/s12888-021-03449-y.
Guzek D, Gła Bska D, Groele B, Gutkowska K. Fruit and vegetable dietary patterns and mental health in women: a systematic review. nutrition reviews. Nutr Rev. 2022;80(6):1357–70. https://doi.org/10.1093/nutrit/nuab007.
Klompmaker JO, Hoek G, Bloemsma LD, Wijga AH, van den Brink C, Brunekreef B, Lebret E, Gehring U, Janssen NAH. Associations of combined exposures to surrounding green, air pollution and traffic noise on mental health. Environ Int. 2019;129:525–37. https://doi.org/10.1016/j.envint.2019.05.040.
Steyerberg EW, Vickers AJ, Cook NR, Gerds T, Gonen M, Obuchowski N, Pencina MJ, Kattan MW. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology. 2010;21(1):128–38. https://doi.org/10.1097/EDE.0b013e3181c30fb2.
Ben Hmido S, Abder Rahim H, Ingwersen EW, Burchell G, Hompes R, van der Peet D, Sonneveld E, Kazemier G, Daams F. Transparency in externally validated models: a systematic review of machine learning vs. logistic regression for predicting colorectal anastomotic leakage. Eur J Surg Oncol. 2025;51(10):110367. https://doi.org/10.1016/j.ejso.2025.110367.
Hess AS, Hess JR. Logistic regression. Transfusion. 2019;59(7):2197–98. https://doi.org/10.1111/trf.15406.
Guo C, Tomson G, Keller C, Söderqvist F. Prevalence and correlates of positive mental health in Chinese adolescents. BMC Public Health. 2018;18(1):263. https://doi.org/10.1186/s12889-018-5133-2.
Dormann CF, Elith J, Bacher S, Buchmann C, Carl G, Carré G, Marquéz JRG, Gruber B, Lafourcade B, Leitão PJ, Münkemüller T, McClean C, Osborne PE, Reineking B, Schröder B, Skidmore AK, Zurell D, Lautenbach S. Collinearity: a review of methods to deal with it and a simulation study evaluating their performance. Ecography. 2013;36(1):27–46. https://doi.org/10.1111/j.1600-0587.2012.07348.x.
Garb HN, Wood JM. Methodological advances in statistical prediction. Psychol Assess. 2019;31(12):1456–66. https://doi.org/10.1037/pas0000673.
Budhkar A, Song Q, Su J, Zhang X. Demystifying the black box: a survey on explainable artificial intelligence (xai) in bioinformatics. Comput Struct Biotechnol J. 2025;27:346–59. https://doi.org/10.1016/j.csbj.2024.12.027.
Amann J, Blasimme A, Vayena E, Frey D, Madai VI. Precise4Q consortium. Explainability for artificial intelligence in healthcare: a multidisciplinary perspective. BMC Med Inf Decis Mak. 2020;20(1):310. https://doi.org/10.1186/s12911-020-01332-6.
Zhang J, Ma X, Zhang J, Sun D, Zhou X, Mi C, Wen H. Insights into geospatial heterogeneity of landslide susceptibility based on the SHAP-XGBoost model. J Environ Manage. 2023;332:117357. https://doi.org/10.1016/j.jenvman.2023.117357.
Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092–97. https://doi.org/10.1001/archinte.166.10.1092.
Shi L, Lu ZA, Que JY, Huang XL, Liu L, Ran MS, Gong YM, Yuan K, Yan W, Sun YK, Shi J, Bao YP, Lu L. Prevalence of and risk factors associated with mental health symptoms among the general population in China during the coronavirus disease 2019 pandemic. JAMA Netw Open. 2020;3(7):e2014053. https://doi.org/10.1001/jamanetworkopen.2020.14053.
Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13. https://doi.org/10.1046/j.1525-1497.2001.016009606.x.
Lu L, Shen H, Tan L, Huang Q, Chen Q, Liang M, He L, Zhou Y. Prevalence and factors associated with anxiety and depression among community-dwelling older adults in Hunan, China: a cross-sectional study. BMC Psychiatry. 2023;23(1):107. https://doi.org/10.1186/s12888-023-04583-5.
Bastien CH, Vallières A, Morin CM. Validation of the insomnia severity index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297–307. https://doi.org/10.1016/s1389-9457(00)00065-4.
Chen H, Feng H, Liu Y, Wu S, Li H, Zhang G, Yang P, Zhang K. Anxiety, depression, insomnia, and PTSD among college students after optimizing the COVID-19 response in China. J Affect Disord. 2023;337:50–56. https://doi.org/10.1016/j.jad.2023.05.076.
Wei YD, Wang Y, Curtis DS, Shin S, Wen M. Built environment, natural environment, and mental health. Geohealth. 2024;8(6):e2024GH001047. https://doi.org/10.1029/2024GH001047.
Viseu J, Leal R, de Jesus Sn, Pinto P, Pechorro P, Greenglass E. Relationship between economic stress factors and stress, anxiety, and depression: moderating role of social support. Psychiatry Res. 2018;268:102–07. https://doi.org/10.1016/j.psychres.2018.07.008.
Walsh R. Lifestyle and mental health. Am Psychol. 2011;66(7):579–92. https://doi.org/10.1037/a0021769.
Campbell F, Blank L, Cantrell A, Baxter S, Blackmore C, Dixon J, Goyder E. Factors that influence mental health of university and college students in the Uk: a systematic review. BMC Public Health. 2022;22(1):1778. https://doi.org/10.1186/s12889-022-13943-x.
Lundberg SM, Erion G, Chen H, DeGrave A, Prutkin JM, Nair B, Katz R, Himmelfarb J, Bansal N, Lee SI. From local explanations to global understanding with explainable ai for trees. Nat Mach Intell. 2020;2(1):56–67. https://doi.org/10.1038/s42256-019-0138-9.
Liu J, Chen L, Chen Y, Luo J, Yu K, Fan L, Yong C, He H, Liao S, Ge Z, Jiang L. Explainable machine learning prediction of internet addiction among Chinese primary and middle school children and adolescents: a longitudinal study based on positive youth development data (2019-2022). Front Public Health. 2025;13:1590689. https://doi.org/10.3389/fpubh.2025.1590689.
R Core Team, Austria V. R: a language and environment for statistical computing. R Foundation for Statistical Computing; 2023. https://www.R-project.org/.
Kuhn M. Building predictive models in R using the caret package. J Stat Softw. 2008;28(5):1–26. https://doi.org/10.18637/jss.v028.i05.
Lang M, Binder M, Richter J, Schratz P, Pfisterer F, Coors S, Au Q, Casalicchio G, Kotthoff L, Bischl B. mlr3: a modern object-oriented machine learning framework in R. J Educ Chang Open Source Softw. 2019;4(44):1903. https://doi.org/10.21105/joss.01903.
Joormann J, Ziobrowski HN, King AJ, Gildea SM, Lee S, Sampson NA, House SL, Beaudoin FL, An X, Stevens JS, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Pi M Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, McGrath ME, Hudak LA, Pascual JL, Seamon MJ, Chang AM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O’Neil BJ, Sanchez LD, Bruce SE, Miller MW, Pietrzak RH, Barch DM, Pizzagalli DA, et al. Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the aurora study. Depress Anxiety. 2022;39(1):56–70. https://doi.org/10.1002/da.23223.
Ormel J, Oerlemans AM, Raven D, Laceulle OM, Hartman CA, Veenstra R, Verhulst FC, Vollebergh W, Rosmalen JG, Reijneveld SA, Oldehinkel AJ. Functional outcomes of child and adolescent mental disorders. Current disorder most important but psychiatric history matters as well. Psychol Med. 2017;47(7):1271–82. https://doi.org/10.1017/S0033291716003445.
Peyton L, Oliveros A, Choi DS, Jang MH. Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders. Exp Mol Med. 2021;53(3):358–68. https://doi.org/10.1038/s12276-021-00587-x.
Jun H, Mohammed Qasim Hussaini S, Rigby MJ, Jang MH. Functional role of adult hippocampal neurogenesis as a therapeutic strategy for mental disorders. Neural Plast. 2012;2012:854285. https://doi.org/10.1155/2012/854285.
Irwin MR. Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol. 2015;66:143–72. https://doi.org/10.1146/annurev-psych-010213-115205.
Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol. 2016;16(1):22–34. https://doi.org/10.1038/nri.2015.5.
Walker WH 2nd, Walton JC, DeVries AC, Nelson RJ. Circadian rhythm disruption and mental health. Transl Psychiatry. 2020;10(1):28. https://doi.org/10.1038/s41398-020-0694-0.
Marx W, Lane M, Hockey M, Aslam H, Berk M, Walder K, Borsini A, Firth J, Pariante CM, Berding K, Cryan JF, Clarke G, Craig JM, Su KP, Mischoulon D, Gomez-Pinilla F, Foster JA, Cani PD, Thuret S, Staudacher HM, Sánchez-Villegas A, Arshad H, Akbaraly T, O’Neil A, Segasby T, Jacka FN. Diet and depression: exploring the biological mechanisms of action. Mol Psychiatry. 2021;26(1):134–50. https://doi.org/10.1038/s41380-020-00925-x.
Razavi Zade M, Telkabadi MH, Bahmani F, Salehi B, Farshbaf S, Asemi Z. The effects of dash diet on weight loss and metabolic status in adults with non-alcoholic fatty liver disease: a randomized clinical trial. Liver Int: Off J Int Assoc For The Study Of The Liver. 2016;36(4):563–71. https://doi.org/10.1111/liv.12990.
Rasmus P, Kozłowska E. Antioxidant and anti-inflammatory effects of carotenoids in mood disorders: an overview. Antioxid (basel). 2023;12(3):676. https://doi.org/10.3390/antiox12030676.
Huang Y, Wang Y, Wang H, Liu Z, Yu X, Yan J, Yu Y, Kou C, Xu X, Lu J, Wang Z, He S, Xu Y, He Y, Li T, Guo W, Tian H, Xu G, Xu X, Ma Y, Wang L, Wang L, Yan Y, Wang B, Xiao S, Zhou L, Li L, Tan L, Zhang T, Ma C, Li Q, Ding H, Geng H, Jia F, Shi J, Wang S, Zhang N, Du X, Du X, Wu Y, et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study. Lancet Psychiatry. 2019;6(3):211–24. https://doi.org/10.1016/S2215-0366(18)30511-X.
Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annu. Rev. Public Health. 2013;34:119–38. https://doi.org/10.1146/annurev-publhealth-031912-114409.
Kiely KM, Brady B, Byles J. Gender, mental health and ageing. Maturitas. 2019;129:76–84. https://doi.org/10.1016/j.maturitas.2019.09.004.
Montero-Marin J, Hinze V, Mansfield K, Slaghekke Y, Blakemore SJ, Byford S, Dalgleish T, Greenberg MT, Viner RM, Ukoumunne OC, Ford T, Kuyken W, Team MYRIAD. Young people’s mental health changes, risk, and resilience during the COVID-19 pandemic. JAMA Netw Open. 2023;6(9):e2335016. https://doi.org/10.1001/jamanetworkopen.2023.35016.
Gong R, Xia D, Hu Z, Hu Y. The impact of neighborhood mental health on the mental health of older adults. BMC Public Health. 2023;23(1):1352. https://doi.org/10.1186/s12889-023-16263-w.
Domínguez-Martinez T, Rascon-Gasca ML, Alcántara-Chabelas H, Garcia-Silberman S, Casanova-Rodas L, Lopez-Jimenez JL. Effects of family-to-family psychoeducation among relatives of patients with severe mental disorders in Mexico city. Psychiatr Serv. 2017;68(4):415–18. https://doi.org/10.1176/appi.ps.201500457.
Moreira TCL, Polize JL, Brito M, da Silva Filho DF, Chiavegato Filho ADP, Viana MC, Andrade LH, Mauad T. Assessing the impact of urban environment and green infrastructure on mental health: results from the São Paulo megacity mental health survey. J Expo Sci Environ Epidemiol. 2022;32(2):205–12. https://doi.org/10.1038/s41370-021-00349-x.
Eleftheriou A, Rokou A, Arvaniti A, Nena E, Steiropoulos P. Sleep quality and mental health of medical students in Greece during the COVID-19 pandemic. Front Public Health. 2021;9:775374. https://doi.org/10.3389/fpubh.2021.775374.
Aiyegbusi OL, Hughes SE, Turner G, Rivera SC, McMullan C, Chandan JS, Haroon S, Price G, Davies EH, Nirantharakumar K, Sapey E, Calvert MJ, TLC Study Group. Symptoms, complications and management of long covid: a review. J R Soc Med. 2021;114(9):428–42. https://doi.org/10.1177/01410768211032850.
Berhe NM, Van de Velde S, Rabiee-Khan F, van der Heijde C, Vonk P, Buffel V, Wouters E, Van Hal G. Knowledge deficit and fear of COVID-19 among higher education students during the first wave of the pandemic and implications for public health: a multi-country cross-sectional survey. BMC Public Health. 2022;22(1):1144. https://doi.org/10.1186/s12889-022-13511-3.
