Video-based AI biomarker (digital aortic stenosis) [AS] severity index [DASSi]According to a study published in ), it may be possible to detect the onset and progression of severe AS in patients undergoing echocardiography or cardiac MRI. JAMA Cardiology. Evangelos K. Oikonomou, MD, DPhil, and colleagues introduced his DASSi to patients with no AS or mild to moderate AS at baseline. The study included 12,599 participants, 8,798 from Yale New Haven Health System (YNHHS) and 3,801 from Cedars-Sinai Medical Center (CSMC). Higher baseline DASSi was associated with faster progression of aortic valve velocity (AV-V).maximum; 0.033 and 0.082 m/s per 0.1 DASSi increment per year for YNHHS and CSMC, respectively); values ≥0.2 are associated with a 4- to 5-fold higher risk of aortic valve replacement compared with values <0.2 ( adjusted).hazard ratio [95 percent confidence intervals],4.97 [2.71 to 5.82] and 4.04 [0.92 to 17.70] for YNHHS and CSMC, respectively). This finding was independent of confounding variables such as age, sex, race, ethnicity, ejection fraction, and AV-V.maximum. This finding was replicated in his 45,474 participants who underwent cardiac MRI examinations at UK Biobank.
