Using machine learning methods to predict 28-day mortality in patients with hepatic encephalopathy | BMC Gastroenterology

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  • American Association for the Study of Liver Diseases; European Association for the Study of the Liver. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases. J Hepatol. 2014;61(3):642–59. https://doi.org/10.1016/j.jhep.2014.05.042.

  • Amodio P. Hepatic encephalopathy: diagnosis and management. Liver Int. 2018;38(6):966–75.

    Article 
    PubMed 

    Google Scholar 

  • Ellul MA, Gholkar SA, Cross TJ. Hepatic encephalopathy due to liver cirrhosis. BMJ (Clin Res Ed). 2015;351:h4187.

    Google Scholar 

  • Vilstrup H, Amodio P, Bajaj J, Cordoba J, Ferenci P, Mullen KD, Weissenborn K, Wong P. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology (Baltimore, MD). 2014;60(2):715–35.

    Article 
    PubMed 

    Google Scholar 

  • Stepanova M, Mishra A, Venkatesan C, Younossi ZM. In-hospital mortality and economic burden associated with hepatic encephalopathy in the United States from 2005 to 2009. Clin Gastroenterol Hepatol. 2012;10(9):1034-1041.e1031.

    Article 
    PubMed 

    Google Scholar 

  • Tapper EB, Finkelstein D, Mittleman MA, Piatkowski G, Chang M, Lai M. A quality improvement initiative reduces 30-day rate of readmission for patients with cirrhosis. Clin Gastroenterol Hepatol. 2016;14(5):753–9.

    Article 
    PubMed 

    Google Scholar 

  • Patidar KR, Thacker LR, Wade JB, Sterling RK, Sanyal AJ, Siddiqui MS, Matherly SC, Stravitz RT, Puri P, Luketic VA, et al. Covert hepatic encephalopathy is independently associated with poor survival and increased risk of hospitalization. Am J Gastroenterol. 2014;109(11):1757–63.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Benhaddouch Z, Abidi K, Naoufel M, Abouqal R, Zeggwagh AA. Mortality and prognostic factors of the cirrhotic patients with hepatic encephalopathy admitted to medical intensive care unit. Ann Fr Anesth Reanim. 2007;26(6):490–5.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Udayakumar N, Subramaniam K, Umashankar L, Verghese J, Jayanthi V. Predictors of mortality in hepatic encephalopathy in acute and chronic liver disease: a preliminary observation. J Clin Gastroenterol. 2007;41(10):922–6.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Findlay JY, Fix OK, Paugam-Burtz C, Liu L, Sood P, Tomlanovich SJ, Emond J. Critical care of the end-stage liver disease patient awaiting liver transplantation. Liver Transpl. 2011;17(5):496–510.

    Article 
    PubMed 

    Google Scholar 

  • Kamath PS, Kim WR. The model for end-stage liver disease (MELD). Hepatology (Baltimore, MD). 2007;45(3):797–805.

    Article 
    PubMed 

    Google Scholar 

  • Biggins SW, Kim WR, Terrault NA, Saab S, Balan V, Schiano T, Benson J, Therneau T, Kremers W, Wiesner R, et al. Evidence-based incorporation of serum sodium concentration into MELD. Gastroenterology. 2006;130(6):1652–60.

    Article 
    PubMed 

    Google Scholar 

  • Beam AL, Kohane IS. Big data and machine learning in health care. JAMA. 2018;319(13):1317–8.

    Article 
    PubMed 

    Google Scholar 

  • Zhang Z, Ho KM, Hong Y. Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care. Criti Care (London, England). 2019;23(1):112.

    Article 

    Google Scholar 

  • Zhang Z. Predictive analytics in the era of big data: opportunities and challenges. Ann Transl Med. 2020;8(4):68.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Goldberger AL, Amaral LA, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE. PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals. Circulation. 2000;101(23):E215-220.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Benchimol EI, Smeeth L, Guttmann A, Harron K, Moher D, Petersen I, Sørensen HT, von Elm E, Langan SM. The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLoS Med. 2015;12(10):e1001885.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jeong JH, Park IS, Kim DH, Kim SC, Kang C, Lee SH, Kim TY, Lee SB. CLIF-SOFA score and SIRS are independent prognostic factors in patients with hepatic encephalopathy due to alcoholic liver cirrhosis. Medicine. 2016;95(26):e3935.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wasmuth HE, Kunz D, Yagmur E, Timmer-Stranghöner A, Vidacek D, Siewert E, Bach J, Geier A, Purucker EA, Gressner AM, et al. Patients with acute on chronic liver failure display “sepsis-like” immune paralysis. J Hepatol. 2005;42(2):195–201.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lin RS, Lee FY, Lee SD, Tsai YT, Lin HC, Lu RH, Hsu WC, Huang CC, Wang SS, Lo KJ. Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation. J Hepatol. 1995;22(2):165–72.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wong F, Bernardi M, Balk R, Christman B, Moreau R, Garcia-Tsao G, Patch D, Soriano G, Hoefs J, Navasa M. Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut. 2005;54(5):718–25.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wan SZ, Nie Y, Zhang Y, Liu C, Zhu X. Assessing the prognostic performance of the child-pugh, model for end-stage liver disease, and albumin-bilirubin scores in patients with decompensated cirrhosis: a large Asian cohort from gastroenterology department. Dis Markers. 2020;2020:5193028.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Peng Y, Wei Q, Liu Y, Wu Z, Zhang H, Wu H, Chai J. Prediction and risk factors for prognosis of cirrhotic patients with hepatic encephalopathy. Gastroenterol Res Pract. 2021;2021:5623601.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bai Z, Guo X, Tacke F, Li Y, Li H, Qi X. Association of serum albumin level with incidence and mortality of overt hepatic encephalopathy in cirrhosis during hospitalization. Ther Adv Gastroenterol. 2019;12:1756284819881302.

    Article 

    Google Scholar 

  • Nardelli S, Gioia S, Ridola L, Farcomeni A, Merli M, Riggio O. Proton pump inhibitors are associated with minimal and overt hepatic encephalopathy and increased mortality in patients with cirrhosis. Hepatology (Baltimore, MD). 2019;70(2):640–9.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zhang Y, Feng Y, Cao B, Tian Q. The effect of small intestinal bacterial overgrowth on minimal hepatic encephalopathy in patients with cirrhosis. Arch Med Sci. 2016;12(3):592–6.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tapper EB, Parikh ND, Sengupta N, Mellinger J, Ratz D, Lok AS, Su GL. A risk score to predict the development of hepatic encephalopathy in a population-based cohort of patients with cirrhosis. Hepatology (Baltimore, MD). 2018;68(4):1498–507.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Labenz C, Toenges G, Huber Y, Nagel M, Marquardt JU, Schattenberg JM, Galle PR, Labenz J, Wörns MA. Development and validation of a prognostic score to predict covert hepatic encephalopathy in patients with cirrhosis. Am J Gastroenterol. 2019;114(5):764–70.

    Article 
    PubMed 

    Google Scholar 

  • de Jongh FE, Janssen HL, de Man RA, Hop WC, Schalm SW, van Blankenstein M. Survival and prognostic indicators in hepatitis B surface antigen-positive cirrhosis of the liver. Gastroenterology. 1992;103(5):1630–5.

    Article 
    PubMed 

    Google Scholar 

  • Magliocchetti N, Torchio P, Corrao G, Aricò S, Favilli S. Prognostic factors for long-term survival in cirrhotic patients after the first episode of liver decompensation. Ital J Gastroenterol Hepatol. 1997;29(1):38–46.

    CAS 
    PubMed 

    Google Scholar 

  • Hung TH, Tseng CW, Tseng KC, Hsieh YH, Tsai CC, Tsai CC. Effect of renal function impairment on the mortality of cirrhotic patients with hepatic encephalopathy: a population-based 3-year follow-up study. Medicine. 2014;93(14):e79.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fichet J, Mercier E, Genée O, Garot D, Legras A, Dequin PF, Perrotin D. Prognosis and 1-year mortality of intensive care unit patients with severe hepatic encephalopathy. J Crit Care. 2009;24(3):364–70.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Guevara M, Baccaro ME, Ríos J, Martín-Llahí M, Uriz J, Ruiz del Arbol L, Planas R, Monescillo A, Guarner C, Crespo J, et al. Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration. Liver Int. 2010;30(8):1137–42.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Guevara M, Baccaro ME, Gómez-Ansón B, Frisoni G, Testa C, Torre A, Molinuevo JL, Rami L, Pereira G, Sotil EU, et al. Cerebral magnetic resonance imaging reveals marked abnormalities of brain tissue density in patients with cirrhosis without overt hepatic encephalopathy. J Hepatol. 2011;55(3):564–73.

    Article 
    PubMed 

    Google Scholar 

  • Riggio O, Angeloni S, Salvatori FM, De Santis A, Cerini F, Farcomeni A, Attili AF, Merli M. Incidence, natural history, and risk factors of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt with polytetrafluoroethylene-covered stent grafts. Am J Gastroenterol. 2008;103(11):2738–46.

    Article 
    PubMed 

    Google Scholar 

  • Cui Y, Guan S, Ding J, He Y, Li Q, Wang S, Sun H. Establishment and evaluation of a model for predicting 3-month mortality in Chinese patients with hepatic encephalopathy. Metab Brain Dis. 2019;34(1):213–21.

    Article 
    PubMed 

    Google Scholar 

  • Cordoba J, Ventura-Cots M, Simón-Talero M, Amorós À, Pavesi M, Vilstrup H, Angeli P, Domenicali M, Ginés P, Bernardi M, et al. Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF). J Hepatol. 2014;60(2):275–81.

    Article 
    PubMed 

    Google Scholar 

  • Saffo S, Garcia-Tsao G. Early mechanical ventilation for grade IV hepatic encephalopathy is associated with increased mortality among patients with cirrhosis: an exploratory study. Acute Crit Care. 2022;37:355–62.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ginès P, Fernández J, Durand F, Saliba F. Management of critically-ill cirrhotic patients. J Hepatol. 2012;56(Suppl 1):S13-24.

    Article 
    PubMed 

    Google Scholar 

  • Pinsky MR. The effects of mechanical ventilation on the cardiovascular system. Crit Care Clin. 1990;6(3):663–78.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bassi TG, Rohrs EC, Reynolds SC. Systematic review of cognitive impairment and brain insult after mechanical ventilation. Crit Care (London, England). 2021;25(1):99.

    Article 

    Google Scholar 

  • Lau T, Ahmad J. Clinical applications of the Model for End-Stage Liver Disease (MELD) in hepatic medicine. Hepat Med. 2013;5:1–10.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Said A, Williams J, Holden J, Remington P, Gangnon R, Musat A, Lucey MR. Model for end stage liver disease score predicts mortality across a broad spectrum of liver disease. J Hepatol. 2004;40(6):897–903.

    Article 
    PubMed 

    Google Scholar 

  • Sarmast N, Ogola GO, Kouznetsova M, Leise MD, Bahirwani R, Maiwall R, Tapper E, Trotter J, Bajaj JS, Thacker LR, et al. Model for end-stage liver disease-lactate and prediction of inpatient mortality in patients with chronic liver disease. Hepatology (Baltimore, MD). 2020;72(5):1747–57.

    Article 
    PubMed 

    Google Scholar 

  • Mahmud N, Asrani SK, Kaplan DE, Ogola GO, Taddei TH, Kamath PS, Serper M. The predictive role of model for end-stage liver disease-lactate and lactate clearance for in-hospital mortality among a national cirrhosis cohort. Liver Transpl. 2021;27(2):177–89.

    Article 
    PubMed 

    Google Scholar 

  • Durand F, Buyse S, Francoz C, Laouénan C, Bruno O, Belghiti J, Moreau R, Vilgrain V, Valla D. Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography. J Hepatol. 2014;60(6):1151–7.

    Article 
    PubMed 

    Google Scholar 



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